无忧传媒

小urrently Olga Dudchenko is a research scientist and assistant professor at Baylor College of Medicine and Rice University (US). Olga is the author of several widely used tools for genome assembly including 3D-DNA, an automated pipeline for using Hi-C data to assemble genomes, and Juicebox Assembly Tools, a system for the visual exploration of Hi-C data which provides a point-and-click interface for using Hi-C heatmaps to identify and correct errors in genome assemblies. She is a cofounder of DNA Zoo (www.dnazoo.org), a consortium focused on facilitating conservation efforts through the rapid generation and release of high-quality genomics resources.

In 2019 MIT Technology Review honoured Olga Dudchenko among 鈥淚nnovators under 35鈥�. Modern gene sequencing machines are very fast, reading through the DNA of a peanut, eggplant, or armadillo in two days. But what they spit out are billions of disorganized fragments of DNA code. Olga Dudchenko has helped to make the next step鈥攑asting those bits together in the right order, to reveal the actual genome鈥攆aster and cheaper.

Dudchenko uses Hi-C, a technique originally developed to study how chromosomes fold, to show which bits of DNA lie physically close to one another. Coupled with Dudchenko鈥檚 methods and algorithms, this makes assembling genomes easy.

In late 2018, Dudchenko and her colleagues shared the first results of DNA Zoo, including end-to-end chromosome sequences for more than 50 species, including the cheetah, red panda, and Brazilian porcupine. In a world of mounting extinction, these species鈥� DNA code may one day be all that鈥檚 left of them.

The job ahead is to characterize the genome of every species on earth. The DNA Zoo (where Dudchenko is referred to as 鈥渃hief zookeeper鈥�) releases new data every week. 鈥淭he ability to [make] decisions in an informed fashion can mean the difference between survival and extinction of the species,鈥� she says.